Oral PDE5 Inhibitors for Erectile Dysfunction

Which one of the oral PDE5 inhibitors is the best choice for treating erectile dysfunction? Sildenafil, Vardenafil, Tadalafil, and Avanafil? What side effects should you be aware of with each type? If you’re still not sure, read on to learn more. If you’re interested in learning more about oral PDE5 inhibitors, you should read this article.


Cenforce contains Sildenafil citrate. Before the development of sildenafil, the only erectile dysfunction treatment options were penile implant surgery and an intracavernosal injection. Both of these procedures are invasive, and patients dreaded them. But serendipity rescued the situation. In 1989, Pfizer scientists synthesized sildenafil citrate, a type of PDE5 inhibitor. Initial results showed that sildenafil reduced vascular resistance and platelet aggregation.

Do you believe Cenforce 100 is effective in treating erectile dysfunction? This prescription medication is a generic variant of Viagra that includes the same active component as Viagra. It works by boosting the flow of blood to the penis. This enables the patient to have hard and long-lasting erections. The tablets also aid in the normalisation of blood flow to the penis, which is beneficial in daily activities.

Sildenafil citrate, an active component, is included in Cenforce 100 Tablet. It works by inhibiting the PDE5 enzyme, which is responsible for producing erections. Many generic brands are available, and it may be obtained at your local drugstore or online. These drugs may be purchased at the best price on the internet. You may also save money by purchasing them from pharmacies with the best pricing.


When taking a PDE5 inhibitor, the penis is relaxed and blood flows through more easily. The process of achieving an erection is complex, but this drug’s vasodilation helps. Nitric oxide, the chemical that leads to erectile dysfunction, is released during sexual arousal. Nitric oxide activates a protein called guanylate cyclase, which in turn stimulates the production of cGMP, an important component in regulating the flow of blood to the penis. This process causes smooth muscle tissues in the corpus cavernosum to relax and increase blood flow to the penis.

Vardenafil is a fast-acting PDE5I that was first introduced to the market in 2003. Its rapid half-life of 4.2 hours makes it a viable oral ED treatment. Its ability to induce an erection is comparable to sildenafil, and its efficacy rate is around 80 percent. It has the added advantage of being more selective than sildenafil.


There are many advantages to taking tadalafil for erectile dysfunction, but there are also some disadvantages. While the effects of these medications are the same, they are marketed differently, which is why pharmacists must be familiar with them. For example, many men may not have a problem using tadalafil. A recent study showed that men who used tadalafil reported higher sexual self-confidence and decreased concerns about timing. However, the researchers found that tadalafil did not seem to affect the quality of erections, and that tadalafil was more effective in improving sexual self-confidence and erectile spontaneity than sildenafil.

This medicine is available as an oral pill and is typically taken once daily. The recommended dose is 2.5-5 mg per day. The medication has a long half-life, which means that the medication can build up in the body. However, tadalafil is generally well tolerated, with 86% of men continuing the medication after six months. Unlike other medications, tadalafil does not interact with fatty foods, so it is safe for people with diabetes or heart disease.


When used in combination with other drugs to treat erectile dysfunction, PDE5 inhibitors are the gold standard for treating erectile dysfunction. They work quickly, last a short period of time, and produce only mild transient side effects. In some cases, PDE5 inhibitors may be prescribed to treat pulmonary hypertension, a condition that affects arteries in the lungs. This condition can lead to shortness of breath, chest pain, and fatigue. In addition, it can lead to a faster heart rate and heart weakness, contributing to heart failure.

In a study by Tsertsvadze et al., PDE5 inhibitors were compared with placebo-controlled placebo trials. Both PDE5 inhibitors improved erectile function. However, the authors noted that while the results of avanafil were statistically significant compared to placebo, the difference in successful intercourse was minimal. The results of these studies were inconsistent, with placebo causing less than one-third of the patients’ erectile dysfunction.

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